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Individual and spatial heterogeneity of praziquantel efficacy against Schistosoma mansoni within the context of repeated mass drug administration

2026-01-05 infectious diseases Title + abstract only
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BackgroundSchistosomiasis control relies on the continued effectiveness of praziquantel (PZQ), yet individual and spatial heterogeneity in PZQ efficacy in the context of repeated mass drug administration (MDA) remains poorly understood. This study aimed to identify individual and spatial determinants of PZQ efficacy against Schistosoma mansoni in rural Uganda. MethodsWe studied 3870 participants aged 5-90 years from 52 villages in Pakwach, Buliisa, and Mayuge districts in Uganda. Participants w...

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