Back
Top 0.1%
24.7%
Top 0.2%
19.7%
#1
16.3%
Top 0.5%
10.4%
Top 14%
7.2%
Top 2%
6.6%
Top 2%
1.7%
Top 96%
1.3%
Top 92%
1.1%
Top 7%
0.6%
Top 13%
0.6%
Top 16%
0.5%
Top 30%
0.5%
Top 29%
0.5%
Top 64%
0.5%
Top 17%
0.5%
Type I interferon drives dysfunction of a distinct CD8+ HLA-DRB1+ T cell subset in systemic lupus erythematosus
2026-01-03
rheumatology
Title + abstract only
View on medRxiv
Show abstract
ObjectiveSystemic lupus erythematosus (SLE) is characterized by persistent type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA-DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN-driven HLA-DRB1 expression and expansion of a distinct CD8+ T cell subset. This study aimed to comprehensively characterize CD8+ HLA-DRB1+ T cells in lupus. MethodsPeripheral blood CD8+ T cells from SLE patients and healthy controls were analyzed by...
Predicted journal destinations
1
Arthritis & Rheumatology
21 training papers
2
Annals of the Rheumatic Diseases
23 training papers
3
JCI Insight
63 training papers
4
Rheumatology
21 training papers
5
Nature Communications
483 training papers
6
Frontiers in Immunology
140 training papers
7
Cell Reports Medicine
49 training papers
8
PLOS ONE
1737 training papers
9
Scientific Reports
701 training papers
10
Journal of Clinical Investigation
50 training papers
11
Nature
58 training papers
12
iScience
74 training papers
13
Frontiers in Medicine
99 training papers
14
Clinical Infectious Diseases
219 training papers
15
eLife
262 training papers
16
eBioMedicine
82 training papers