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SCAMPI: A scalable and accessible micropatterning platform for reproducible organoid morphogenesis

Cantoni, F.; Fiori, M.; Mattolini, L.; Janssen, D.; Ramis Bravo, E.; Sgualdino, F.; Van Lent, J.; Lammertyn, J.; Ranga, A.

2025-12-29 bioengineering
10.64898/2025.12.29.696843 bioRxiv
Show abstract

Micropatterning technologies enable biomimetic organoid generation with controlled in vitro morphogenesis but current approaches lack scalability. Here, we develop a mask-based photopatterning platform to enhance organoid culture reproducibility and scalability on diverse substrate formats. We demonstrate its use in generating architecturally defined neural organoids of varying geometries with reproducible morphogenesis. This technology provide a versatile and low-cost strategy for generating geometrically controlled organoids.

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