The Global Parkinson's Disease Genetics (GP2) Genome Browser
Fang, Z.-H.; Grant, R. H.; Vitale, D.; Hernandez, C. F.; Hong, S.; Leonard, H. L.; Makarious, M. B.; Lange, L. M.; Solomonson, M.; Heutink, P.; Dilliott, A. A.; Galvelis, K. G.; Nalls, M. A.; Singleton, A. B.; Blauwendraat, C.; Global Parkinson's Genetics Program (GP2),
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BackgroundLarge-scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinsons disease (PD) risk and disease-causing variants, we developed an open-access, summary-level genomic data browser. MethodsWe performed uniform joint variant calling to harmonize whole-genome sequencing (WGS) data from AMP-PD Release 4, GP2 Data Releases, and additional controls from the Alzheimers Disease Sequencing Project. Clinical exome sequencing (CES) data from GP2 Release 8 was also included. ResultsThe integrated dataset includes 31,665 WGS and 9,559 CES samples, spanning eleven ancestries and over 300 million variants. ConclusionThe GP2 Genome Browser is a lightweight, flexible platform providing intuitive gene- and variant-level summaries with ancestry-stratified allele frequencies and functional annotations. It is open source and freely accessible at https://gp2.broadinstitute.org, enabling broad access to PD genomic data and supporting global research efforts.
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