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Large Language Model-Driven Prioritization of Alzheimer's Disease Drug Targets Across Multidimensional Criteria

2025-12-29 health informatics Title + abstract only
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Large language models (LLMs) offer new opportunities to synthesize the vast and heterogeneous biomedical literature, yet their potential to support drug target prioritization in complex diseases such as Alzheimers disease (AD) remains largely unexplored. Here, we introduce an LLM-driven framework that evaluates and ranks AD therapeutic targets across six criteria central to pharmaceutical decision-making: biological confidence, technical feasibility, clinical developability, patient impact, comp...

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