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Intermediate rectal dose exposure as a predictor of late toxicity after prostate stereotactic body radiotherapy: a principal component analysis of dose volume histogram
2025-12-29
oncology
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Background and purposeStereotactic body radiotherapy (SBRT) has become a standard treatment option for localized prostate cancer, with low rates of clinically relevant late toxicity. However, the identification of robust dosimetric predictors of toxicity remains challenging due to the high dimensionality and collinearity of dose-volume histogram (DVH) metrics. This study aimed to explore whether principal component analysis (PCA) of DVHs can identify dose regions associated with late gastrointes...
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