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Automation in Clinical Trial Statistical Programming: A Structured Review of TLF Generation, Validation Frameworks, and AI/ML Integration

2025-12-29 health informatics Title + abstract only
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BackgroundClinical trial statistical programming is transitioning from manual, study-specific coding toward metadata-driven, automated pipelines. Although general data management transformation has been reviewed, comprehensive synthesis of statistical programming automation--particularly tables, listings, and figures (TLF) generation and validation frameworks--remains limited. This review addresses this gap through systematic evidence synthesis. MethodsWe conducted a structured literature revie...

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