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Unraveling Genetic Variants underlying Schizophrenia Phenotypes: An Original GWAS in Hong Kong Chinese with Cross-Ethnic Meta-Analysis and Predictive Modeling

2025-12-31 genetic and genomic medicine Title + abstract only
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BackgroundSchizophrenia (SCZ) is a highly heritable and heterogeneous disorder with diverse clinical presentations and cognitive deficits. The specific genetic variants contributing to this variability remain largely unknown. This study aims to uncover the genetic bases of various clinical phenotypes such as age at onset (AAO), positive/negative symptoms, self-harm and aggression in SCZ using genome-wide association studies (GWAS). Few large-scale GWAS have explored these phenotypes, especially ...

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