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Associations between disease-specific polygenic risk scores and disease-specific causes of death in the UK Biobank cohort

2025-12-23 epidemiology Title + abstract only
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1.Disease-specific Polygenic Risk Scores (PRS) are usually evaluated against the incidence of diseases they were derived for. Individuals may be more interested in how these PRS influence their probable cause of death. Using UK Biobank data, we examined the top 10 causes of death among individuals in the highest quintile of disease-specific PRS for Alzheimers disease, bowel cancer, cardiovascular disease, coronary artery disease, ischaemic stroke, breast cancer, epithelial ovarian cancer, and pr...

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