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CRISPR-Cas12a Assay for Rapid and Specific Detection of Shigella flexneri 2a in Clinical Samples

2025-12-22 infectious diseases Title + abstract only
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Shigella flexneri 2a is the most common cause of shigellosis, a major public health concern in developing countries. Rapid and reliable diagnostic tools are critical for timely outbreak detection and management. Leveraging Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology, we developed a CRISPR-Cas12a-based assay for the rapid and specific detection of S. flexneri 2a and validated its performance using stool specimens from patients. Two guide RNAs targeting the gtrII ...

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