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Exploring Machine Learning Models to Uncover Pathways in ALS Pathogenesis Using Immunohistochemical Features

2025-12-27 health informatics Title + abstract only
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Amyotrophic Lateral Sclerosis (ALS) is a degenerative disease of motor neurons that leads to muscle wasting, paralysis, and death, with an average life expectancy of 2-5 years. Approximately 10-15% of ALS cases are familial (fALS), typically linked to, but not always caused by identifiable inherited genetic mutations. The remaining 85-90% are considered sporadic ALS (sALS), which typically occurs without a clear family history. It is thought to result from a combination of genetic and non-geneti...

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