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Hormonal contraception and SSRIs influence on oxytocin and cortisol reactivity to stress in patients with borderline personality disorder

2025-12-20 psychiatry and clinical psychology Title + abstract only
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BackgroundBorderline personality disorder (BPD) involves emotional instability and stress sensitivity linked to oxytocinergic and HPA-axis dysregulation. This study examined oxytocin and cortisol responses to acute psychosocial stress and the modulatory effects of SSRIs and hormonal contraception. Methods93 female participants (45 with BPD with/without SSRIs and 48 healthy controls) underwent the Trier Social Stress Test. Linear and generalized linear mixed-effects models were applied to assess...

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