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Integrative Profiling of Glymphatic Dysfunction in Adolescent Subthreshold Depression

2025-12-27 psychiatry and clinical psychology Title + abstract only
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ObjectiveSubthreshold depression (StD) in adolescence is a potent risk factor for major depressive disorder, yet its neurobiological mechanisms remain unclear. The glymphatic system, a brain-wide waste clearance pathway, has been implicated in psychiatric disorders but has not been investigated integratively in StD. This study aimed to characterize glymphatic function in adolescents with StD using a multimodal neuroimaging approach. MethodsA total of 107 adolescents (71 with StD and 36 healthy ...

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