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Comparing computable structured phenotype- versus large language model-identification of opioid use disorder using electronic health record data

2025-12-19 emergency medicine Title + abstract only
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Study ObjectiveTo compare a computable structured opioid use disorder (OUD) phenotype currently used to trigger emergency department (ED) clinical decision support (CDS) with a large language model (LLM) for OUD identification, using expert physician review as the reference standard. MethodsWe conducted a retrospective study of randomly sampled adult ED encounters (January 1, 2023-October 17, 2024) at a single academic health system. Encounters were stratified by structured phenotype status and...

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