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Internal and External Validation of Comprehensive High-Frequency Activity Biomarkers for Epilepsy Surgery

2025-12-19 neurology Title + abstract only
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Although epilepsy surgery studies have proposed intracranial EEG-derived biomarkers for localizing seizure onset and anticipating postoperative outcomes, evaluation has often been limited to derivation cohorts using internal cross-validation. An influential notion holds that neurons distributed within the seizure onset zone (SOZ) frequently generate high-frequency activity (HFA) and that resection of such sites is associated with favorable postoperative seizure control. However, the extent to wh...

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