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Beyond Annotation: Leveraging Raw RNA-seq Reads via Foundation Models for Multi-Cancer Early

2025-12-18 oncology Title + abstract only
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Early cancer detection substantially improves patient survival, yet conventional screening methods are directed at single anatomical sites and inadequately screen 45.5% of cases. Cell-free RNA (cfRNA) from blood offers a promising, non-invasive avenue for early cancer detection, reflecting real-time transcriptional activity from tumors. However, most RNA-seq pipelines focus exclusively on annotated genes, ignoring the 98% of the human genome comprising unannotated regions including noncoding RNA...

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