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Peripheral Metabolic-Redox Signaling as a Core Mechanism of Major Depressive Disorder: Evidence From Deep Metabolomic Phenotyping

2025-12-17 psychiatry and clinical psychology Title + abstract only
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BackgroundMajor depressive disorder (MDD) is a neuro-immune, oxidative, and nitrosative stress (NIMETOX) disorder, in which peripheral immune-redox pathways intersect with metabolic networks leading to neurotoxicity within the limbic-prefrontal affective circuits. Comprehensive metabolomics analysis in well-phenotyped patients is vital to elucidate their metabolic profile. ObjectivesTo identify metabolic abnormalities that differentiate inpatients with severe MDD from healthy controls through h...

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