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Treatment Resistant Depression in electronic health records: Definitions Matter

2025-12-15 psychiatry and clinical psychology Title + abstract only
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BackgroundMany people with depression do not respond well to the first antidepressant prescribed. Treatment Resistant Depression (TRD) refers to depression which does not respond to multiple subsequent antidepressant treatments. Identifying TRD in routinely-collected health records is challenging due to limited response-related data. Previous studies have used definitions based on the number of antidepressant switches observed. However, these do not account for other features clinically indicati...

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