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A Blind Trajectory Scan Identifies VSIG10L and Reactivation of Developmental Programs in Prediagnostic Alzheimer Disease

2025-12-15 geriatric medicine Title + abstract only
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BackgroundWhile blood-based biomarkers for Alzheimers Disease (AD) such as p-Tau and NfL characterize established pathology, the systemic biological cascade triggering these events remains incompletely mapped. We hypothesized that proteins exhibiting a rising trajectory in the prodromal phase might reveal novel mechanisms of disease progression. MethodsUsing data from the UK Biobank Pharma Proteomics Project (N = 4,519 incident AD cases), we performed a blind trajectory scan of [~]3,000 plasma ...

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