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Global and local genetic correlation between congenital heart disease and neurodevelopmental disorders shared genetic architecture

2025-12-15 genetic and genomic medicine Title + abstract only
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Individuals with congenital heart disease (CHD) have an increased risk of neurodevelopmental disorders (NDDs), a relationship likely driven by multiple interacting factors, including shared genetic influences, the underlying cardiac malformation, and risks associated with medical and surgical care. To investigate the genetic component of this association, we analyzed genome-wide association study (GWAS) summary statistics for CHD from the UK Biobank and FinnGen, focusing on two phenotypes presen...

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