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Multi-Ancestry GWAS of Neuroticism Identifies Novel Loci and Enhances Fine-Mapping Resolution

2025-12-15 genetic and genomic medicine Title + abstract only
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Neuroticism is a core personality trait linked to emotional instability and increased risk for anxiety, depression, and schizophrenia. Most genome-wide association studies (GWAS) have focused on European populations, limiting the discovery of ancestry-specific genetic influences. To address this gap, we conducted the most diverse multi-ancestry GWAS meta-analysis of neuroticism to date, analyzing 668,780 individuals across African (AFR), European (EUR), East Asian (EAS), and South Asian (SAS) po...

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