Back

GenomoBase: an integrated resource for Genomoviridae genomics and metagenomics

Cardenas-Conejo, Y.

2025-12-12 molecular biology
10.64898/2025.12.11.693732 bioRxiv
Show abstract

The family Genomoviridae comprises circular single-stranded DNA viruses reported from fungi, plants, animals and environmental samples. Although metagenomics has accelerated their discovery, genomic sequences, annotations and metadata remain dispersed across repositories. Here we present GenomoBase (https://www.genomobase.org), a curated resource that integrates genomic, ecological and bibliographic data for all 237 ICTV-recognized genomovirus species. GenomoBase incorporates Serratus-filtered SRA screening outputs, enabling prioritization of metagenomes for targeted re-analysis. As a proof of concept, a targeted bait-and-assemble workflow of one prioritized SRA run recovered two complete genomes, both below the 78% species demarcation threshold for genomoviruses. GenomoBase streamlines comparative analyses and metagenome-guided genome recovery.

Published in Virology (predicted rank #10) · training set

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

50% of probability mass above

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.