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Influence of Binarization Process on Vascular Density Metrics: A Quantitative Optical Coherence Tomography Angiography Assessment in Human and Porcine Retinas
2025-12-15
anesthesia
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BackgroundOptical Coherence Tomography Angiography (OCTA) provides high-resolution visualization of retinal microvasculature, with vascular density (VD) serving as a one of the key quantitative metrics. However, VD measurements are highly sensitive to image binarization step, and no standardized approach exists. MethodsWe analyzed 51 OCTA scans (human and porcine) using 29 binarization algorithms, including global and local thresholding techniques from ImageJ and DoxaPy, as well as Random Walke...
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