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Hereditary Diffuse Gastric Cancer (HDGC) and Prophylactic Total Gastrectomy (PTG): Clinicopathological Outcomes and Long-term Impact on Weight and Health-Related Quality of Life

2025-12-12 surgery Title + abstract only
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ImportanceHereditary diffuse gastric cancer (HDGC) is predominantly due to germline CDH1 variants and confers a high lifetime risk of diffuse gastric cancer (DGC). Prophylactic total gastrectomy (PTG) is thought to prevent DGC but has potential long-term functional, nutritional and quality-of-life (QOL) sequelae. ObjectiveWe report the clinical, pathological and long-term weight and QOL outcomes from a prospective cohort of patients with HDGC who underwent PTG. Design and SettingThis is a sing...

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