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Helping Underdeveloped Lungs with Cells (HULC)-2 Mesenchymal Stromal Cells in extreme preterm infants at risk of developing Bronchopulmonary Dysplasia. A Phase 2 Multi-Centre Double Blind Randomized Controlled Trial Study Protocol.
2025-12-15
pediatrics
Title + abstract only
View on medRxiv
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IntroductionBronchopulmonary dysplasia (BPD) remains a major complication among extremely low gestational age (ELGA) infants, with long-term respiratory and neurodevelopmental consequences. Despite advances in neonatal care, effective therapies to prevent BPD are lacking. Mesenchymal stromal cells (MSC), particularly those derived from umbilical cord (UC-MSC), offer promise due to their pleiotropic effects. Preclinical and early-phase clinical studies have demonstrated safety and potential effic...
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