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Clofazimine population pharmacokinetics and target attainment in rifampicin-resistant Tuberculosis patients
2025-12-05
pharmacology and therapeutics
Title + abstract only
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Clofazimine is a key component of the BPaLC regimen (bedaquiline, pretomanid, linezolid, and clofazimine), an investigational treatment for rifampicin-resistant tuberculosis (RR-TB). However, clofazimines elimination half-life has never been formally characterized amongst tuberculosis patients and a pharmacokinetic (PK) - pharmacodynamic (PD) endpoint for probability of target attainment (PTA) evaluations is lacking. To support dose optimization and efficacy interpretation, we developed a clofaz...
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