The International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) Portal: An Open Source Resource for Neuropsychological Research in Epilepsy

BackgroundThe International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) is a consensus-based, empirically-driven approach to standardize cognitive phenotyping in epilepsy research that has quickly garnered interest within the epilepsy community. However, manually generating IC-CoDE phenotypes in group data is laborious and time-consuming, particularly in datasets containing heterogenous cognitive measures or batteries, limiting the widespread adoption of IC-CoDE phenotypes to further multicenter epilepsy research. Methods/ResultsTo remove this barrier, we developed the IC-CoDE portal (https://ic-code-portal.ccf.org/), an interactive and user-friendly, web-based platform to support the scientific community in performing IC-CoDE individual level classification through web interface or bulk classification through upload of data files. The portal also allows the user to generate and visualize cohort summary statistics of cognitive phenotypes in their dataset, with the option of filtering the data interactively by specified demographic or clinical variables of interest. We further made the resulting IC-CoDE phenotypes downloadable as a spreadsheet to foster offline analysis of cognitive data by members of the epilepsy research community. SignificanceAscertainment of cognitive profiles is key to understanding the natural heterogeneity in the clinical presentation of the epilepsies and their comorbidities. The IC-CoDE taxonomy can be applied to any comprehensive neuropsychological battery, regardless of the specific test measures and normative data used or the language and culture in which the assessment took place, making it an ideal tool to accelerate international multi-center studies on cognition in epilepsy. We hope that by eliminating some of the barriers associated with cognitive phenotyping, the IC-CoDE portal will springboard large-scale collaborative efforts to further our understanding of the neuropsychology of the epilepsies.