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Direct synthesis of self-organized blastocyst-like cysts derived from human pluripotent stem cells

Wen, X.; Terada, S.; Yoshimoto, K.; Kamei, K.-i.

2019-11-05 bioengineering
10.1101/831487 bioRxiv
Show abstract

We introduce a simple, robust and scalable method to generate self-organized blastocyst-like cysts (soBLCs) from human pluripotent stem cells (hPSCs). We use a copolymer hydrogel of poly(N-isopropylacrylamide) and poly(ethylene glycol) (PNIPAAm-PEG). hPSC aggregates with a diameter of approximately 117.2 {+/-} 5.1 {micro}m are cultured in a medium supplemented with a hydrogel and a serum for three days. Molecular signatures in the medium revealed the generation of trophoblasts and inner cell mass at specific positions in the soBLCs.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.