Identification of a novel tedizolid resistance mutation in rpoB of methicillin-resistant Staphylococcus aureus
Shen, T.; Penewit, K.; Waalkes, A.; Xu, L.; Salipante, S.; Nath, A.; Werth, B. J.
Show abstract
A tedizolid-resistant isolate of MRSA was selected by serial passage. Whole genome sequencing revealed only a single nucleotide variant in rpoB. Cross-resistance to linezolid, chloramphenicol, and quinupristin-dalfopristin was observed but susceptibility to other drugs including rifampin was unchanged. Models of the RNA-polymerase-ribosomal complex revealed that the mutated residue was unlikely to interact directly with the oxazolidinone binding site. This is the first time that rpoB mutation has been associated with resistance to the PhLOPSa antimicrobials.
Matching journals
The top 1 journal accounts for 50% of the predicted probability mass.
Similar papers in this journal
- Microevolution of acquired colistin resistance in Enterobacteriaceae from ICU patients receiving selective decontamination of the digestive tract. 95%
- Heme is crucial for medium-dependent metronidazole resistance in clinical isolates of C. difficile 95%
- Enhanced Activity of Apramycin and Apramycin-Based Combinations Against Mycobacteroides abscessus 94%
Similar papers in this journal
- Assessing antibiotic tolerance of Staphylococcus aureus derived directly from patients by the Replica Plating Tolerance Isolation System- REPTIS 94%
- Klebsiella pneumoniae mutants resistant to ceftazidime/avibactam plus aztreonam, imipenem/relebactam, meropenem/vaborbactam and cefepime/taniborbactam. 93%
- Reconciling the potentially irreconcilable? Genotypic and phenotypic amoxicillin-clavulanate resistance in Escherichia coli 93%
Similar papers in this journal
- A Panel of Diverse Pseudomonas aeruginosa Clinical Isolates for Research and Development 92%
- Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired 90%
- The appropriateness of empirical antibiotic therapy in the management of symptomatic urinary tract infection patients-A cross sectional study in Nairobi County, Kenya 90%
Similar papers in this journal
- Antimicrobial Susceptibilities of Clinical Bacterial Isolates from Urinary Tract Infections to Fosfomycin and Comparator Antibiotics Determined by Agar Dilution Method and Automated Micro Broth Dilution 94%
- Identification of plasmid-mediated tigecycline resistance tet(x4) and New Delhi Metallo-β-lactamase (NDM) in an Escherichia coli isolate from Canada 93%
- Novel Anti-virulence Compounds Disrupt Exotoxin Expression in MRSA 93%
Similar papers in this journal
- Opening Pandora box - high level resistance to antibiotics of last resort in Gram negative bacteria from Nigeria 91%
- In vitro synergistic action of TAT-RasGAP317-326 peptide with antibiotics against Gram-negative pathogens 90%
- A Novel Air-Dried Multiplex High Resolution Melt Assay For The Detection Of Extended Spectrum Beta-Lactamase And Carbapenemase Genes 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.