Phenotypic and Genotypic Antiviral Resistance Testing of HSV-1 Causing Recurrent Cutaneous Lesions in a Patient with DOCK8 Deficiency
Casto, A. M.; Stout, S. C.; Selvarangan, R.; Freeman, A. F.; Newell, B. D.; Stahl, E. D.; Greninger, A. L.; Yin, D. E.
Show abstract
Antiviral resistance frequently complicates treatment of herpes simplex virus (HSV) infections in immunocompromised patients. Here we review the case of an adolescent boy with dedicator of cytokinesis 8 (DOCK8) deficiency, who experienced recurrent infections with resistant HSV-1. We used both phenotypic and genotypic methodologies to characterize the resistance profile of HSV-1 in the patient and conclude that genotypic testing outperformed phenotypic testing. We also present the first analysis of intrahost HSV-1 evolution in an immunocompromised patient. While HSV-1 can remain static in an immunocompetent individual for decades, the virus from this patient rapidly acquired genetic changes throughout its genome.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Antiviral CD19+CD27+ Memory B Cells Are Associated with Protection from Recurrent Asymptomatic Ocular Herpes Infection 92%
- In vivo generation of BK and JC polyomavirus defective viral genomes in human urine samples associated with higher viral loads 92%
- Feline leukemia virus (FeLV) endogenous and exogenous recombination events result in multiple FeLV-B subtypes during natural infection 90%
Similar papers in this journal
- Virologic characterization of symptom rebound following nirmatrelvir-ritonavir treatment for COVID-19 91%
- Infection with the SARS-CoV-2 Delta Variant is Associated with Higher Infectious Virus Loads Compared to the Alpha Variant in both Unvaccinated and Vaccinated Individuals 91%
- Generation of novel SARS-CoV-2 variants on B.1.1.7 lineage in three patients with advanced HIV disease 91%
Similar papers in this journal
- Longitudinal SARS-CoV-2 testing is punctuated by intermittent positivity and variable rates of cycle-threshold decline 92%
- Herpes simplex virus 1 strain 17+ with R2 mutation in UL37 has residual retrograde transport 91%
- The impact of early anti-SARS-CoV-2 antibody production on the length of hospitalization stay among COVID-19 patients 90%
Similar papers in this journal
- Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion 93%
- A case-cluster of aseptic meningitis associated with a newly identified recombinant echovirus6/CoxsackievirusB1 enterovirus 92%
- Frequent development of broadly neutralizing antibodies in early life in a large cohort of HIV-infected children 91%
Similar papers in this journal
- CD8+ T cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants 90%
- The longest persistence of viable SARS-CoV-2 with recurrence of viremia and relapsing symptomatic COVID-19 in an immunocompromised patient – a case study 90%
- Genomic surveillance of SARS-CoV-2 in a university community: insights into tracking variants, transmission, and spread of Gamma (P.1) variant 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.