Combinations of antifungals to effectively kill drug-resistant Candida auris
Jaggavarapu, S.; Burd, E. M.; Weiss, D. S.
Show abstract
Candida auris is an emerging, highly virulent fungal pathogen that is often resistant to multiple classes of antifungals. To overcome this resistance, we investigated the in vitro efficacy of antifungal combinations, finding that amphotericin B/micafungin resulted in drastically reduced survival (~5 logs) of all 10 isolates tested including 2 that were refractory to each individual drug. These findings suggest that combination therapy with micafungin/amphotericin B may have clinical utility against broadly resistant C. auris.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- In vitro Evaluation of Antifungal Drug Combinations against Multidrug-resistant Candida auris isolates from New York Outbreak 97%
- Evaluation of in vitro activity of manogepix against multidrug-resistant and pan-resistant Candida auris from the New York Outbreak 96%
- Vaginal Isolates of Candida glabrata are Uniquely Susceptible to Ionophoric Killer Toxins Produced by Saccharomyces cerevisiae. 95%
Similar papers in this journal
- Abrogation of pathogenic attributes in drug resistant Candida auris strains by farnesol 94%
- A screening of the MMV Pathogen Box(R) reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis 94%
- Analysis of the Mutant Selection Window and Killing of Mycoplasma hyopneumoniae for Doxycycline, Tylosin, Danofloxacin, Tiamulin, and Valnemulin 94%
Similar papers in this journal
- In Vitro Evidence to Support Amphotericin B and Flucytosine Combination Therapy for Talaromycosis 97%
- Molecular Epidemiology and Microbiological Characteristics of Cryptococcus gattii VGII isolates from China 94%
- The development of a novel diagnostic PCR for Madurella mycetomatis using a comparative genome approach 93%
Similar papers in this journal
- Differential growth rates and in vitro drug susceptibility to currently used drugs for multiple isolates of Naegleria fowleri 94%
- CanID-PCR: A quick and low-cost PCR tool to identify Candida species on gDNA directly extracted from positive blood bottles 94%
- Antimicrobial Susceptibilities of Clinical Bacterial Isolates from Urinary Tract Infections to Fosfomycin and Comparator Antibiotics Determined by Agar Dilution Method and Automated Micro Broth Dilution 93%
Similar papers in this journal
- Bisphosphonates synergistically enhance the antifungal activity of azoles in dermatophytes and other pathogenic molds 95%
- A Nanoemulsion as an Effective Treatment Against Human Pathogenic Fungi 94%
- Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.