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Computational approaches for parametric imaging of dynamic PET data

Crisci, S.; Piana, M.; Ruggiero, V.; Scussolini, M.

2019-08-28 bioengineering
10.1101/748806 bioRxiv
Show abstract

Parametric imaging of nuclear medicine data exploits dynamic functional images in order to reconstruct maps of kinetic parameters related to the metabolism of a specific tracer injected in the biological tissue. From a computational viewpoint, the realization of parametric images requires the pixel-wise numerical solution of compartmental inverse problems that are typically ill-posed and nonlinear. In the present paper we introduce a fast numerical optimization scheme for parametric imaging relying on a regularized version of the standard affine-scaling Trust Region method. The validation of this approach is realized in a simulation framework for brain imaging and comparison of performances is made with respect to a regularized Gauss-Newton scheme and a standard nonlinear least-squares algorithm.

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