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Mapping the plasma proteomic architecture of systemic lupus erythematosus
2025-11-19
rheumatology
Title + abstract only
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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by autoantibodies to nuclear antigens. SLE is highly heterogeneous, both clinically and immunologically, yet the molecular basis underlying this remains incompletely understood. To address this, we profiled the plasma proteome in 260 SLE patients and 86 healthy volunteers (HVs) using the SomaScan v4.1 platform, quantifying 7,288 analytes corresponding to 6,595 unique proteins. We identified 215 proteins that were r...
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