Back

Novel markers of cognitive impairment and resilience using digital and plasma biomarkers across different neurodegenerative diseases

Toniolo, S.; Zhao, S.; Broulidakis, M.; Gendarini, C.; Sinha, D.; Tahira, N.; Scholcz, A.; Amein, B.; Fower, A.; Van Duijn, C.; Thompson, S.; Manohar, S. G.; Koychev, I.; Husain, M.

2025-11-15 neurology
10.1101/2025.11.13.25340143 medRxiv
Show abstract

Blood-based biomarkers enable early diagnosis of neurodegenerative diseases in a cost-effective and non-invasive way. Digital cognitive measures can capture early signs of cognitive impairment remotely and at scale. Their combination offers important opportunities for effective screening. We evaluated the performance of a new proteomic assay and a fully remote digital platform in a large memory clinic population (n = 391). Plasma biomarkers were measured using the NUcleic acid Linked Immuno-Sandwich Assay (NULISA) central nervous system panel. OCTAL (Oxford Cognitive Testing Portal) digital cognitive testing platform was used to measure cognition. Distinct proteomic patterns could be identified across different neurodegenerative diseases and associate with specific cognitive functions. Alzheimers Disease (e.g., pTau217), and novel proteomics biomarkers (e.g., ACHE and IL6R) were highly correlated with worse cognition. A cluster of biomarkers, including PRDX6, was overexpressed in healthy controls and associated with better cognition, indexing cognitive resilience.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
Alzheimer's & Dementia
177 papers in training set
Top 0.1%
40.0%
2
Alzheimer's Research & Therapy
○ 57 papers in training set
Top 0.3%
5.5%
Similar papers in this journal
3
Nature Communications
○ 5641 papers in training set
Top 26%
5.5%
Similar papers in this journal
50% of probability mass above
4
Brain Communications
◐ 166 papers in training set
Top 0.6%
5.5%
Similar papers in this journal
5
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
○ 42 papers in training set
Top 0.2%
5.2%
Similar papers in this journal
6
Brain
◐ 168 papers in training set
Top 0.9%
4.4%
7
Molecular Psychiatry
○ 282 papers in training set
Top 3%
2.5%
8
eBioMedicine
○ 183 papers in training set
Top 2%
2.4%
9
Scientific Reports
○ 3612 papers in training set
Top 45%
2.1%
10
Nature Aging
○ 60 papers in training set
Top 0.9%
1.7%
11
The Journal of Prevention of Alzheimer's Disease
○ 13 papers in training set
Top 0.3%
1.5%
12
Acta Neuropathologica
○ 58 papers in training set
Top 1%
1.1%
13
Alzheimer's & Dementia: Translational Research & Clinical Interventions
○ 17 papers in training set
Top 0.4%
1.1%
14
Communications Medicine
○ 113 papers in training set
Top 3%
1.1%
15
npj Digital Medicine
○ 118 papers in training set
Top 3%
1.0%
16
Journal of Alzheimer's Disease
○ 48 papers in training set
Top 0.9%
1.0%
17
Communications Biology
○ 993 papers in training set
Top 26%
1.0%
18
Molecular Neurodegeneration
○ 55 papers in training set
Top 2%
0.9%
19
Annals of Neurology
○ 64 papers in training set
Top 2%
0.9%
20
npj Parkinson's Disease
○ 105 papers in training set
Top 1%
0.9%
21
Acta Neuropathologica Communications
○ 89 papers in training set
Top 2%
0.9%
22
Journal of Neurology, Neurosurgery & Psychiatry
● 30 papers in training set
Top 0.7%
0.9%
23
npj Systems Biology and Applications
○ 125 papers in training set
Top 2%
0.6%
24
Journal of Alzheimer’s Disease
○ 50 papers in training set
Top 1%
0.6%