Back

Scalable flow synthesis of ultrasmall inorganic nanoparticles for biomedical applications via a confined impinging jet mixer

Kian, A. C.; Gupta, M.; Hong, H.; Rivera, K. L. L.; Pandey, N.; Mossburg, K. J.; Rosario-Berrios, D. N.; Maidment, P.; Hanna, A. R.; Singh, P.; Xiang, Z.; Issadore, D.; Maidment, A.; Koo, H.; Cormode, D.

2025-11-13 bioengineering
10.1101/2025.11.12.688080 bioRxiv
Show abstract

Ultrasmall inorganic nanoparticles (sub-5 nm) have unique biomedical advantages due to rapid clearance, enhanced imaging contrast, and potent therapeutic properties. However, current synthesis methods are limited by low throughput, polydispersity, and reliance on harsh conditions such as organic solvents or high temperatures. We report a scalable, single-step aqueous synthesis using a confined impinging jet mixer (CIJM) that produces size-controlled, clinically relevant nanoparticles, including silver sulfide, silver telluride, cerium oxide, and iron oxide, under ambient conditions. The resulting nanoparticles are homogeneous, stable, and preserve their functional biological properties. We demonstrate consistent performance across scales, establishing the CIJM as a versatile and reproducible method for producing ultrasmall inorganic nanoparticles suitable for clinical translation and high-throughput biomedical applications.

Published in Scientific Reports (predicted rank #17) · training set

Matching journals

The top 7 journals account for 50% of the predicted probability mass.

1
ACS Nano
● 113 papers in training set
Top 0.1%
14.9%
Similar papers in this journal
2
Advanced Functional Materials
○ 46 papers in training set
Top 0.1%
9.6%
Similar papers in this journal
3
ACS Applied Materials & Interfaces
● 39 papers in training set
Top 0.1%
8.8%
Similar papers in this journal
4
Nanoscale Advances
● 15 papers in training set
Top 0.1%
5.1%
Similar papers in this journal
5
Small
○ 78 papers in training set
Top 0.3%
4.0%
6
Nano Letters
● 71 papers in training set
Top 0.3%
4.0%
7
Nanoscale
● 42 papers in training set
Top 0.2%
4.0%
Similar papers in this journal
50% of probability mass above
8
Advanced Science
○ 286 papers in training set
Top 2%
3.5%
9
Advanced Materials
○ 56 papers in training set
Top 0.3%
3.5%
10
Journal of Controlled Release
○ 44 papers in training set
Top 0.3%
3.2%
11
Advanced Healthcare Materials
○ 85 papers in training set
Top 0.7%
2.7%
12
Nature Communications
○ 5641 papers in training set
Top 38%
2.6%
13
ACS Applied Bio Materials
● 24 papers in training set
Top 0.3%
2.4%
14
Science Advances
● 1243 papers in training set
Top 15%
2.4%
15
ACS Biomaterials Science & Engineering
● 37 papers in training set
Top 0.5%
1.7%
16
ACS Central Science
● 71 papers in training set
Top 1.0%
1.3%
Scientific Reports · published here
○ 3612 papers in training set
Top 60%
1.3%
18
Biomaterials Science
● 24 papers in training set
Top 0.5%
1.1%
19
Nature Nanotechnology
○ 32 papers in training set
Top 0.5%
1.1%
20
Analytical Chemistry
● 218 papers in training set
Top 2%
1.1%
21
Advanced Therapeutics
○ 17 papers in training set
Top 0.2%
1.0%
22
ACS Omega
● 105 papers in training set
Top 3%
1.0%
23
Journal of Colloid and Interface Science
○ 12 papers in training set
Top 0.3%
0.8%
24
Bioconjugate Chemistry
● 20 papers in training set
Top 0.3%
0.8%
25
Journal of the American Chemical Society
● 217 papers in training set
Top 3%
0.8%
26
ACS Sensors
● 49 papers in training set
Top 0.7%
0.8%
27
Photoacoustics
○ 12 papers in training set
Top 0.3%
0.8%
28
European Journal of Nuclear Medicine and Molecular Imaging
○ 20 papers in training set
Top 0.2%
0.6%
29
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 45%
0.6%
30
Langmuir
● 36 papers in training set
Top 0.7%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.