Estimating the sensitivity of non-treponemal and treponemal antibody tests in primary syphilis
Sweitzer, S. F.; Chen, J. S.; Matoga, M. M.; Yang, L.; Lopez-Medina, E.; Garcia-Luna, J. A.; Hoffman, I. F.; Yang, B.; Salazar, J. C.; Radolf, J. D.; Parr, J. B.; Sena, A. C.
Show abstract
Among patients with primary syphilis, sensitivity of TRUST was 55% (6/11) compared to darkfield microscopy (DFM) and 60% (9/15) compared to Treponema pallidum PCR. Sensitivity of RPR was 78% (38/49) and 93% (43/46), respectively. TPPA had a sensitivity of 95% (41/43) compared to DFM and 96% (43/45) compared to PCR. Short SummaryCompared to direct detection methods for the diagnosis of primary syphilis, TRUST has low sensitivity, RPR has moderate to good sensitivity, and TPPA has high sensitivity.
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