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Do 5' regions of human protein-coding genes contain the blueprints for alternative splicing?

Thomas, W.; Moulinier, L.; Scalzitti, N.; Thompson, J.; Chennen, K.; Poch, O.

2025-11-03 bioinformatics
10.1101/2025.11.01.686005 bioRxiv
Show abstract

To investigate alternative splicing capacity, we statistically compared the properties of human protein-coding genes with multiple transcript isoforms (MISOG) and single transcript isoforms (SISOG). Apart from global exon content, differential features are concentrated in the 5 gene regions, with MISOG presenting complex 5 untranslated region architecture and a distinctive flanking environment around first 5 intron. Importantly, we found that 5 exons are more prone to alternative splicing in MISOG. These results unravel previous observations indicating the importance of 5 gene regions in some transcriptional processes and call for their reassessment in light of the MISOG/SISOG profiles.

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