Class switching toward IgG4 six months after primary mRNA-based COVID-19 vaccination in kidney patients

2025-10-28 nephrology Title + abstract only

Show abstract

BackgroundClass switching toward spike (S)-binding IgG4 antibodies after mRNA-based COVID-19 vaccination has been observed, an antibody subclass with strong neutralizing but limited effector activity. While this has been reported in healthy individuals, subclass dynamics in immunocompromised kidney patients are unclear. We assessed IgG subclass patterns and S-specific B-cell phenotypes up to 6 months after a two-dose mRNA-1273 vaccination schedule in kidney transplant recipients (KTRs), dialysis...

Class switching toward IgG4 six months after primary mRNA-based COVID-19 vaccination in kidney patients

Predicted journal destinations