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Ensilication preserves high-molecular weight native DNA for clinical long-read sequencing

2025-11-03 genetic and genomic medicine Title + abstract only
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Long-read DNA sequencing detects genetic variants and epigenetic modifications simultaneously, but optimal preservation of molecular length and base modifications typically requires cold-chain infrastructure. This infrastructure dependence restricts genomics to well-resourced laboratories and limits field research. We show that ensilication, the encapsulation of DNA within silica matrices, preserves DNA integrity at ambient temperature equivalent to -80 {degrees}C freezing. Using Genome-in-a-Bot...

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