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Symptoms of problematic alcohol use differ in their genetic associations with comorbid internalizing, externalizing, and neurodevelopmental psychiatric disorders
2025-10-22
addiction medicine
Title + abstract only
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Background and AimsCertain symptoms of problematic alcohol use (PAU) show associations with comorbid internalizing and externalizing disorders even after controlling for their common PAU factor. Outsized associations between PAU indicators and comorbid psychopathology may reflect distinct etiologic pathways or measurement characteristics that, if unaccounted for, could bias comorbidity estimates with PAU. Although these issues could represent a source of bias in estimates of genetic correlation ...
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