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Endoscopic Predictors of Early Cancer Burden Allow Optimization of Management Decisions in Hereditary Diffuse Gastric Cancer

2025-10-15 gastroenterology Title + abstract only
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IntroductionHereditary diffuse gastric cancer (HDGC) associated with CDH1 germline pathogenic variants (GPV), carries a high lifetime risk of signet ring cell carcinoma (SRCC). Currently, there is uncertainty regarding to whom and when to recommend prophylactic total gastrectomy (PTG). We hypothesise a small number of early SRCC lesions correlates with low risk of progression to clinical gastric cancer. This study aimed to identify predictors of early SRCC burden and provide evidence to inform b...

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