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The Rural Adversity and Determinants Index: A Novel Assessment Method of At-Risk Rural Counties

Krishna, E. S. C.; Manjrekar, A.; Araujo, N.; La, Q. D.

2025-10-13 public and global health
10.1101/2025.10.10.25337725 medRxiv
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IntroductionSignificant rural health disparities are driven by social determinants of health (SDOH), yet existing tools like the CDCs Social Vulnerability Index (SVI) and USDAs Rural-Urban Continuum Codes (RUCC) inadequately capture rural-specific adversity due to national-level aggregation and geographic oversimplification. This study develops and validates the Rural Adversity and Determinants Index (RADI), a novel composite SDOH index tailored for U.S. rural counties. We hypothesized RADI would outperform SVI and RUCC in predicting adverse health outcomes and uniquely explain rural health disparities. MethodsUsing 1,210 non-metropolitan U.S. counties (RUCC >3), RADI was constructed via Principal Component Analysis from 18 SDOH metrics spanning income, education, infrastructure, and healthcare access. Validation against five health outcomes (premature mortality, poor/fair health, infant mortality, heart disease mortality, preventable hospital stays) included bivariate correlations, single-predictor linear regressions (comparing RADI, SVI, and RUCC via R2), and multivariable regressions testing RADIs unique contribution after controlling for SVI/RUCC. ResultsRADI significantly outperformed SVI and RUCC across all outcomes. For premature mortality, RADI explained 55.6% of variance versus SVI (37.3%) and RUCC (2.4%); for poor/fair health, RADI R2 reached 77.2% versus SVI (50.1%). RADI correlated strongly with SVI (r = 0.708) but captured distinct adversity dimensions: RADI scores increased with geographic isolation ({beta} = 0.0278, p<0.001 for RUCC), while SVI unexpectedly decreased ({beta} = -0.4279, p=0.024) at high rurality. In multivariable models, RADI remained a highly significant predictor after controlling for SVI/RUCC (e.g., for premature mortality: {beta} = 95.29, p<0.001), whereas RUCC lost significance for most outcomes. ConclusionsRADI is a rigorously validated, rural-specific SDOH index that more accurately quantifies adversity than national tools. By exposing modifiable drivers like infrastructure deficits and healthcare access gaps, RADI enables precise targeting of policies and resources to reduce rural health inequities. Future work should integrate RADI into funding frameworks and expand its use in longitudinal and intervention studies

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