Back

Mu-opioid receptor availability in patients with opioid use disorder treated with either methadone or buprenorphine

2025-10-08 addiction medicine Title + abstract only
View on medRxiv
Show abstract

Methadone (MET) and buprenorphine (BUP)--mu-opioid receptor (MOR) agonists--are efficacious treatments for opioid use disorder (OUD). Using high-sensitivity, long axial field-of-view PET imaging with [11C]carfentanil, we compared MOR availability in 5 MET and 5 BUP patients and 13 healthy controls (HCs) in five brain regions: ventral tegmentum, thalamus, caudate, putamen, and amygdala. MOR availability differed across groups (F10,34=5.6, p<0.001) and was lower in BUP patients than HCs across all...

Predicted journal destinations

1
Drug and Alcohol Dependence
21 training papers
Top 0.2% 18.0%
2
Neuropsychopharmacology
29 training papers
#1 12.0%
3
Translational Psychiatry
94 training papers
Top 2% 11.1%
4
Addiction
24 training papers
Top 0.6% 6.5%
5
Biological Psychiatry
36 training papers
Top 0.9% 6.0%
6
JAMA Network Open
125 training papers
Top 1% 6.0%
7
Frontiers in Psychiatry
56 training papers
Top 3% 5.1%
8
PLOS ONE
1737 training papers
Top 81% 5.1%
9
Molecular Psychiatry
84 training papers
Top 3% 5.1%
10
Brain Stimulation
27 training papers
Top 0.6% 4.2%
11
Scientific Reports
701 training papers
Top 80% 2.0%
12
Human Brain Mapping
53 training papers
Top 4% 2.0%
13
Brain
69 training papers
Top 7% 1.5%
14
Imaging Neuroscience
18 training papers
Top 2% 1.0%
15
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
27 training papers
Top 4% 1.0%
16
Cerebral Cortex
15 training papers
Top 1% 0.7%