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Effects of Non-Cardiac/Non-neurologic Surgery and Anaesthesia on the CSF Proteome, and Modulation by the APOE Mimetic Peptide CN-105
2025-10-07
surgery
Title + abstract only
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BackgroundNeuroinflammation is thought to contribute to postoperative central nervous system (CNS)-related complications, and the apolipoprotein E (APOE)-mimetic peptide CN-105 blocks neuroinflammation in animal models. Thus, here we examined postoperative cerebrospinal fluid (CSF) proteome changes and their modulation by CN-105. ObjectiveTo evaluate postoperative changes in the CSF proteome, and their modulation by the APOE mimetic peptide CN-105. MethodsWe performed mass spectrometry-based p...
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