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Evidence for Aerosolized Environmental Bacterial Endotoxin as an Environmental Health Hazard

Yisrael-Gayle, K.; Helderop, E. E.; Morin, C.; Polk, D.; Qiu, X.; Dingilian, H.; del Castillo, D.; Penuelas, V.; Topacio, T. M.; Freund, L.; Drover, R.; Gonzalez, D.; Alaama, S. T.; Husari, A.; McGowan, E.; Merwyn, R.; Botthoff, J.; Shapiro, M.; Kongari, R.; Aronson, E.; Godzik, A.; LeComte-Hinely, J.; Wei, R.; Cocker, D.; Lo, D. D.

2025-10-05 occupational and environmental health
10.1101/2025.10.02.25337178 medRxiv
Show abstract

The high incidence of asthma near Californias Salton Sea is attributed to dust emitted from the exposed lakebed. A survey of clinical symptoms conducted in the region revealed distinct spatial distribution with strong geospatial correlations between asthma symptoms and prevailing wind direction as well as with PM10 levels. Mice exposed to dust collected across the region showed lung inflammation which was TLR4-dependent; dust inducing the strongest inflammation showed the highest concentrations of LPS. Inflammatory responses and LPS distribution showed a distinct spatial distribution. Environmental halophiles cultured from Salton Sea water produced LPS that induced similar lung inflammation in mice. These results suggest that environmental bacterial LPS entrained in the dust promotes asthma-like disease; thus, perturbations of "natural" ecosystems may produce significant health impacts.

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
Environmental Research
○ 49 papers in training set
Top 0.1%
18.8%
Similar papers in this journal
2
Environmental Health Perspectives
● 17 papers in training set
Top 0.1%
12.7%
Similar papers in this journal
3
PLOS ONE
● 5266 papers in training set
Top 19%
9.1%
Similar papers in this journal
4
Scientific Reports
○ 3612 papers in training set
Top 8%
7.4%
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5
mBio
● 833 papers in training set
Top 2%
7.4%
Similar papers in this journal
50% of probability mass above
6
Annals of the American Thoracic Society
● 11 papers in training set
Top 0.1%
6.9%
7
Science of The Total Environment
○ 186 papers in training set
Top 0.8%
4.9%
8
American Journal of Physiology-Lung Cellular and Molecular Physiology
● 43 papers in training set
Top 0.3%
2.8%
9
Environmental Pollution
○ 37 papers in training set
Top 0.4%
2.5%
10
Applied and Environmental Microbiology
● 339 papers in training set
Top 3%
1.9%
11
Environment International
○ 43 papers in training set
Top 0.4%
1.8%
12
Ecotoxicology and Environmental Safety
○ 10 papers in training set
Top 0.1%
1.8%
13
The FASEB Journal
○ 194 papers in training set
Top 3%
1.7%
14
Environmental Science & Technology Letters
● 21 papers in training set
Top 0.1%
1.5%
15
American Journal of Respiratory Cell and Molecular Biology
◐ 43 papers in training set
Top 0.5%
1.4%
16
Indoor Air
○ 10 papers in training set
Top 0.1%
1.4%
17
BMC Research Notes
○ 33 papers in training set
Top 0.7%
1.1%
18
PNAS Nexus
◐ 159 papers in training set
Top 3%
0.9%
19
mSystems
● 394 papers in training set
Top 6%
0.9%
20
Brain, Behavior, & Immunity - Health
○ 28 papers in training set
Top 0.5%
0.9%
21
Toxicological Sciences
◐ 41 papers in training set
Top 0.5%
0.9%
22
European Respiratory Journal
● 59 papers in training set
Top 1%
0.6%
23
iScience
○ 1154 papers in training set
Top 39%
0.6%
24
BMJ Open
● 601 papers in training set
Top 13%
0.6%
25
Toxicology and Applied Pharmacology
○ 14 papers in training set
Top 0.3%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.