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Genetic overlap between treatment-resistant schizophrenia and smoking initiation

2025-09-27 psychiatry and clinical psychology Title + abstract only
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Early detection of treatment-resistant schizophrenia (TRS) is of substantial clinical importance. While TRS is heritable, the associated genetic variants have been difficult to identify. Cigarette smoking is associated with non-response to antipsychotics, and smoking behavior and schizophrenia have a shared genetic basis. Thus, TRS may also have a shared genetic basis with smoking behavior. Here we aim to identify genetic variants associated with TRS, by leveraging overlapping genetic variants w...

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