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A Large-Scale Pharmacogenomic Knowledge Graph For Drug-Gene-Variant-Disease Discovery

2025-09-25 genetic and genomic medicine Title + abstract only
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AO_SCPLOWBSTRACTC_SCPLOWPrecision therapeutics depends on the ability to reason jointly over genes, variants, drugs, diseases, adverse drug reactions (ADRs), and molecular pathways without contaminating evaluation with future knowledge. I present a large-scale pharmacogenomic knowledge graph (PGx-KG) that integrates PharmGKB, ClinVar, SIDER, and Reactome--harmonized to HGNC, RxNorm, MeSH, and ChEBI identifiers--yielding 3,744,727 nodes and 9,645,367 edges across six major relation families. A le...

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