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Tangible advantages of multi-stage brain motion compensation for PET imaging demonstrated in multiple studies

2025-09-19 radiology and imaging Title + abstract only
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Head motion is a persistent challenge in positron emission tomography (PET) brain imaging, reducing quantitative accuracy, degrading time-activity curves (TACs), and complicating kinetic modeling. We evaluated a fully automated, multi-stage motion compensation framework, COMBRA (Correction of Motion and BRain Alignment), across more than one hundred scans and four independent PET studies using different radiotracers (18F-MK-6240, 11C-Raclopride, 11C-PBR28, and 11C-Martinostat). COMBRA implements...

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