Back

Anterior Talofibular Ligament and Calcaneofibular Ligament Repair Reinforced by Bio-inductive Implants

Taseh, A.; Aslan, L.; Chegini Kord, M. H.; Al Masri, M.; Hedayatzadeh Razavi, A.; Nafisi, N.; O Neill, C.; Toy, K.; Batista, J.; Waryasz, G.; Miller, C. P.; Nazarian, A.; Ashkani Esfahani, S.

2025-09-12 orthopedics
10.1101/2025.09.11.25335447 medRxiv
Show abstract

BackgroundChronic lateral ankle instability stems from laxity in the anterior talofibular (ATFL) and calcaneofibular (CFL) ligaments. While suture repair is standard, added reinforcement is often needed to restore native strength. This study evaluates the biomechanics bio-inductive implant augmentation (Bio-Aug) of suture repair. MethodsEight fresh-frozen human ankle specimens were tested under three ATFL and CFL conditions, including: (1) Intact, (2) Suture-Repair, and (3) Bio-Aug, (BioBrace(R), CONMED Co, Largo, FL). Biomechanical testing included a 500-cycle loading protocol, with creep, primary stiffness, and final stiffness as outcomes. ResultsOnly 32% of Suture-Repair specimens completed all 500 cycles, compared to full completion in other groups (P = .04). Bio-Aug results were comparable to Intact, while Suture-Repair showed lower final stiffness than Bio-Aug (P = .049). The Intact group had the least creep, although Suture-Repair showed high variability. ConclusionBio-inductive implant appears to provide comparable stiffness to native ligaments by reinforcing suture repair.

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
Journal of Orthopaedic Research
21 papers in training set
Top 0.1%
19.3%
2
PLOS ONE
5266 papers in training set
Top 17%
11.5%
3
Journal of Biomechanics
64 papers in training set
Top 0.1%
8.2%
4
Applied Sciences
25 papers in training set
Top 0.1%
6.5%
5
Acta Biomaterialia
92 papers in training set
Top 0.4%
4.5%
50% of probability mass above
6
Scientific Reports
3612 papers in training set
Top 28%
3.7%
7
Cureus
68 papers in training set
Top 1.0%
3.7%
8
Journal of Anatomy
29 papers in training set
Top 0.1%
3.4%
9
BMJ Open
601 papers in training set
Top 6%
3.4%
10
PeerJ
308 papers in training set
Top 3%
2.8%
11
Journal of the Mechanical Behavior of Biomedical Materials
24 papers in training set
Top 0.2%
2.6%
12
Annals of Biomedical Engineering
37 papers in training set
Top 0.5%
1.8%
13
Journal of Clinical Medicine
97 papers in training set
Top 2%
1.8%
14
Frontiers in Sports and Active Living
11 papers in training set
Top 0.2%
1.8%
15
Bioengineering
29 papers in training set
Top 0.5%
1.5%
16
Journal of Biomechanical Engineering
20 papers in training set
Top 0.4%
1.2%
17
Bone
25 papers in training set
Top 0.3%
1.1%
18
Clinical Epidemiology
10 papers in training set
Top 0.3%
1.0%
19
Trials
29 papers in training set
Top 0.8%
1.0%
20
IEEE Transactions on Biomedical Engineering
40 papers in training set
Top 0.8%
1.0%
21
IEEE Transactions on Neural Systems and Rehabilitation Engineering
49 papers in training set
Top 0.8%
1.0%
22
Journal of NeuroEngineering and Rehabilitation
36 papers in training set
Top 0.7%
0.9%
23
Disability and Rehabilitation
11 papers in training set
Top 0.4%
0.9%
24
Arthritis Research & Therapy
15 papers in training set
Top 0.2%
0.9%
25
eLife
5828 papers in training set
Top 63%
0.9%
26
BJGP Open
13 papers in training set
Top 0.6%
0.6%
27
Journal of Biomedical Materials Research Part A
20 papers in training set
Top 0.6%
0.5%
28
Science Translational Medicine
127 papers in training set
Top 5%
0.5%
29
Journal of The Royal Society Interface
235 papers in training set
Top 5%
0.5%
30
Frontiers in Bioengineering and Biotechnology
98 papers in training set
Top 3%
0.5%