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A Re-Appraisal of Three Network Meta-Analyses to Explain the Discrepancy in Findings for the Efficacy of Fluoxetine for the Treatment of Depression in Children and Adolescents
2025-09-09
psychiatry and clinical psychology
Title + abstract only
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ObjectiveTo explain discrepant findings for fluoxetines efficacy in three influential network meta-analyses (NMAs) of treatments for pediatric depression, which led to conflicting clinical recommendations. DesignCritical appraisal and re-analysis of three published NMAs. Data sourcesNMAs published in two Lancet journals and in Cochrane, together with the trial datasets reported therein. Data synthesisWe compared efficacy estimates for fluoxetine versus placebo across NMAs. We identified and a...
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